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From Hammarlund Lab
Welcome to the Hammarlund Lab
We study neuronal survival, regeneration and degeneration using a genetics and cell-biology approach in the model organism C. elegans. Our long-term goal is to understand how neurons regulate their response to injury, disease, and age, and to identify ways to control these responses at the molecular level.
We use a broad array of tools, including novel RNAi-based techniques, single-neuron laser surgery and optogenetics. Because C. elegans is transparent and has a simple nervous system, we can manipulate and observe individual neurons in intact, living animals.
A major current focus in the lab is understanding the genetics and cell biology of axon regeneration. We have identified several novel regeneration pathways, and are working to link regeneration to functional recovery; to understand how age affects regenerative potential; and to use genetics and genomics to identify additional components of regeneration.
News
2012
January 25: Rachid's paper, Notch Signaling Inhibits Axon Regeneration, published in Neuron! PDF
Neuron Preview by Po, Calarco, and Zhen: PDF
January 10: Yale undergrad Trent Walradt joins the lab. Welcome Trent!
2011
December 19: Happy Holidays from the Hammarlund lab! (Cookies by Rebecca Brown from the CNNR Bakeoff)
July 30: End of the 2011 Hammarlund Lab Summer Undergrad Program. Thanks to Jaimie, Quinn, Reba, and Yigit!
July 13: Sara passes her qualifying exams. Congratulations!
May 19: Alex and Tyson's paper, In vivo Laser Axotomy in C. elegans, published in the Journal of Visualized Experiments! movie PDF
May 6: Goodbye to new Yale Graduate and amazing lab member Ellie Hong!
2010
December 9: Some of Marc's work from his first postdoc (Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE–Sec1/Munc18 membrane fusion complex) published in PNAS
November 11: Chris passes his qualifying exam. Congratulations Chris!
November 5: Genetics Department Annual Retreat at Jiminy Peak. Faculty photo
October 19: Some of Chris' work from college (Modifiers of notch transcriptional activity identified by genome-wide RNAi) published in BMC Developmental Biology
August 12: Welcome postdoc Yasunori Saheki!
August 9: With a small tear in his eye, Dan heads west for a Visiting Assistant Professor position at Linfield College. Good Luck Dan!!
June 27-30: Neuronal Development, Synaptic Function, and Behavior C. elegans Topic Meeting.
June 15: Some of Alex's work from grad school (MADD-2, a Homolog of the Opitz Syndrome Protein MID1, Regulates Guidance to the Midline through UNC-40 in Caenorhabditis elegans) published in Developmental Cell
June 14: Welcome grad student Sara Kosmaczewski!
May 24: Welcome undergraduate Ellie Hong!
April 27: Tyson passes his qualifying exam. Congratulations Tyson!
2009
October 6: Welcome postdoc Alexandra Byrne!
June 24-28: International C. elegans Meeting
June 10: "Imaging Axon Regeneration in vivo", Yale Microscopy Workshop
May 18: Welcome grad student Tyson Edwards!
May 7: Welcome grad student Christopher Firnhaber!
April 24: Arnold and Mabel Beckman Foundation Young Investigator Award.
Jan. 22: "Axon regeneration requires a conserved MAP kinase pathway" published in Science. PDF
Jan. 12: Welcome technician Laura Klein!
2008
Dec. 12: Genetics Department Holiday Party
Dec. 11: CNNR Open House
The fact is the sweetest dream that labor knows. --Robert Frost
